84-1038-49　［取扱停止］CENP-F (Centromere protein F , CENPF, centromere protein F (350/400kD, mitosin), CENF, PRO1779, mitosin, AH antigen, CENP-F kinetochore protein, centromere protein F (400kD), cell-cycle-dependent 350K nuclear protein) 50ul　C2615-20

特徴

• The kinetophore is a macromolecular structure that is associated with the centromeres of chromosomes and is responsible for establishing and maintaining the connections with the microtubules of the mitotic spindle.
• The proteins that reside within the chromosomal domain fall into two broad classes: those that associate with the centromere throughout the cell cycle and those that are found at the centromere in a cell cycle specific manner.
• Members of the first class include CENP-A, CENP-B, and CENP-C.
• The members of the second class include several ubiquitous cellular proteins such as calmodulin, tubulin, dynein and p34 cdc2 and also CENP-E and CENP-F.
• CENP-F appears to be the earliest member to interact with the centromere-kinetochore complex.
• CENP-F also shows a cell-cycle distribution that is both temporally regulated and diverse in terms of the structural components it localizes to and therefore may play a role in several mitotic events.
• (1-3)
• Cellular Localization:As cells progress through S phase, weak nuclear staining is observed.
• In G2 phase, very bright CENP-F staining is detected uniformly throughout the nucleus but excluded from the nucleoli.