High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis.
The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester.
SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism.
In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
Applications:Suitable for use in Immunofluorescence, Flow Cytometry, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:FACS: 1:100 Western Blot: 1:1000-1:5000Immunohistochemistry (Paraffin): 1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
Specificity：Recognizes mouse SR-BI. Species crossreactivity: rat , mink and hamster SR-BI and the long form of human CLA-I.
Isotype：IgG
Calc Applications Abbrev：E FC IHC WB
Calc Crossreactivity：Hm Hu Mo Rt
Immunogen：A peptide containing residues 496-509 from mouse Scavenger Receptor-BI plus an N-terminal cysteine was coupled to KLH. CSPAAKGTVLQEAKL-COOH.
