84-1038-45　Scavenger Receptor BII (SR-BII) 100ul　S0099-010

特徴

• High density lipoproteins (HDLs) play a critical role in cholesterol metabolism.
• HDL plasma concentrations are inversely correlated with risk for atherosclerosis.
• SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene.
• SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain is almost completely different.
• SR-BII binds HDLs mediating selective uptake of HDL cholesteryl ester; with an approximately 4-fold lower efficiency than SR-BI.
• Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI.
• SR-BII expression found in liver, adrenal glands, and testes.
• The role of SR-BII is not completely clear.
• Research suggests that it may be a functional HDL receptor.
• SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer of lipid between HDL and cells.
• The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells (1-6).
• Applications:Suitable for use in Immunohistochemistry, Immunocytochemistry, Western Blot and Immunofluorescence.
• Knockdown Validated.
• Other applications not tested
• Recommended Dilution:Western Blot: 1:1000.
• A band of ~82kD is seen in tissues that express SR-BII such as liver, tested and adrenal glands
• Immunofluorescence (IC): 1:25-1:100Immunohistochemistry (paraffin): 1:25Optimal dilution determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.