High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis.
The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester.
SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism.
In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
Applications:Suitable for use in Western Blot and Immunoprecipitation.
Not suitable for Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
Positive Control:HL-60 cells
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：mouse
Grade：Serum
Purity：Serum.
Form：Supplied as a liquid, 0.05% sodium azide.
Specificity：Recognizes mouse SR-BI (~82kD). Species Crossreactivity: rat and hamster SR-BI
Isotype：IgG
Calc Applications Abbrev：IP WB
Calc Crossreactivity：Hm Mo Rt
Immunogen：Peptide containing residues 496-509 (CSPAAKGTVLQEAKL-COOH) from mouse SR-BI plus an N-terminal cysteine was coupled to KLH.
