Neurofibromin is a product of the tumor suppressor gene, Neurofibromatosis type I.
Neurofibromin is known to have GTPase activity that modulates the ras pathway.
The absence of or alteration of the neurofibromin protein may lead to Neurofibromatosis disease.
This protein has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.
Western Blot (1:500-1:2,000), showing a band-set at 200-240kD and 450kD, and Immunohistochemistry of frozen and paraffin sections (1:200-1:500).
This antibody does not require antigen retrieval methods.
仕様
Size：500ul
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
Specificity：Specific for neurofibromin. Species crossreactivity: Reacts with human, mouse and rat neurofibromin.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A highly conserved N-terminal peptide, corresponding to amino acids 27-41 of human neurofibromin, QQNTHTKVSTEHNKE(C)
