Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis.
Hormonal melatonin has been implicated in sleep and circadian clock function, and acts as ìthe hormone of the night.î Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina (1,2).
Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein.
Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity.
This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans (3).
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Antiserum was eluted in 0.1N glacial acetic acid containing 0.1% BSA and neutralized using 10X PBS containing NaOH to a final pH of 6.8.
Specificity：Specific for primate AANAT. Species crossreactivity: Recognizes human, rhesus AANAT. It does not recognize rat, sheep, chicken or zebrafish AANAT.
