Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations.
Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA.
The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites.
A homologue of E.
coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity.
The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines.
Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
Positive control: K562 cell extracts , Hela cell extracts.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.
Specificity：Specific for NTH1. Species crossreactivity: Reacts with human NTH1. There is sequence homology to mouse.
