The function of the delta-opioid receptors has not been determined.
However, recent studies in rodents have linked delta-opioid receptor antagonists with prevention of morphine tolerance and dependence without relinquishing mu-opioid antinociception.
In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response.
The opioid signal is transduced from receptors through G proteins to various different effectors.
Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal.
For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.
Applications:Suitable for use in Immunoprecipitation.
Other applications have not been tested.
Recommended Dilution:Immunoprecipitation: 1:250-12000Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at 4°C for short-term only.
Reconstitute to nominal volume by adding sterile 40-50% glycerol, PBS, 10mg/ml BSA., aliquot and store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size:100ul
Host:rabbit
Source Antibody:human
Grade:Serum
Purity:Serum.
Form:Supplied as a lyophilized powder. Reconstitute with 100ul sterile, 40-50% glycerol, PBS, 10mg/ml BSA.
Specificity:Recognizes Opioid Receptor, delta, CT, aa360-372. Recognizes Delta Opioid Receptor (aa360-372) 100%; Delta Opioid Receptor: 60%; Mu Opioid Receptor: 0%; Kappa Opioid Receptor: 0%. Species crossreactivity: Rat.
Isotype:IgG
Calc Applications Abbrev:IP
Calc Crossreactivity:Hu Rt
Immunogen:Synthetic peptide corresponding to the carboxyl terminal of the delta opioid receptor (carrier protein).