84-1037-87　［取扱停止］PRKDC (DNA-activated Serine/threonine Protein Kinase) 50ug　P9003

特徴

• DNA-activated serine/threonine protein kinase (DNA-PK) is a nuclear protein kinase that is involved in DNA nonhomologous end joining (NHEJ) required for double- strand brake repair and V(D)J recombination.
• DNA-PK is composed of a large catalytic subunit of ~470 kD (DNA-PKcs) and a DNA binding heterodimer of approximately 70- and 80-kD subunits called Ku.
• (1-2).
• Autophosphorylation of DNA-PK correlates with loss of protein kinase activity and dissociation of the DNA-PKcs-Ku complex.
• DNA-PK phosphorylates Hsp90, p53 and c-Jun (3-4).
• Applications:Suitable for use in Immunohistochemistry, Immunocytochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: Frozen sections.
• Not tested for paraffin.
• 1:100-1:1000Immunocytochemistry: 1:100-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.