Highly conserved and ubiquitously expressed 14–3–3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction.
A novel transcriptional co-activator, TAZ (transcriptional co-activator with PDZ-binding motif) functions as a 14–3–3-binding molecule.
TAZ may link events at the plasma membrane and cytoskeleton to nuclear transcription in a manner that can be regulated by 14–3–3.
Applications:Suitable for use in Western Blot.
Other applications have not been tested.
Recommended Dilution:Western Blot: 1:250-1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage, store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide before the addition of glycerol to 40%.
Specificity：Reacts with residues 386–400, which is the PDZ-binding domain of the 49kDa human TAZ protein.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide, aa386–400, which is the PDZ-binding domain of the 49kDa human TAZ protein.
