A novel Death Effector Domain-containing protein, DEDD2, is closest in amino acid sequence homology to Death Effector Domain-containing DNA-binding protein, DEDD.
DEDD2 is expressed widely in adult human tissues with highest levels in liver, kidney and peripheral blood leukocytes.
DEDD2 interacts with FLIP, but not with FADD or Caspase 8.
Over-expression of DEDD2 induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas(CD95/APO-1), TRAIL(Apo2L), or FADD.
These findings suggest that DEDD2 is involved in the regulation of nuclear events mediated by the extrinsic apoptosis pathway.
Applications:Suitable for use in ELISA, Western Blot.
Other applications have not been tested
Recommended Dilution:Western Blot: 1:250-1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage, store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide before the addition of 40% glycerol.
Specificity：Reacts with residues 144–129 of the DEDD2 protein.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide, aa144–129 of the DEDD2 protein.
