84-1033-03　［取扱停止］Bcl 10 (B Cell Leukemia 10, CIPER, mE10, CARMEN, CLAP) 100ug　B0807-12

特徴

• Apoptosis is related to many diseases including cancer.
• Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases.
• CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase 9, and caspase 2.
• A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP (1-6).
• Bcl 10 is a cellular homolog of the equine Herpes virus-2 E-10 gene.
• Overexpression of Bcl10 induces JNK, p38, and NF-kB activation.
• Bcl 10 interacts with caspase 9 and enhances pro-caspase-9 processing and induces apoptosis through caspase 9 activation.
• Bcl 10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy .
• Bcl 10 is expressed in many human and murine tissues and cell lines.
• Bcl 10 is identified through its direct involvement in t(1;14)(p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma.
• It is also expressed both in normal lymphoid tissue but doesn’t exhibit crossreactivity with other tissues except breast.
• In non-malignant B-cell follicles the protein is expressed in the cytoplasm of the germinal center B-cells, while in MALT lymphomas with t(1;14)(p22;q32), Bcl 10 expression can be detected both in nucleus and cytoplasm.
• Applications:Suitable for use in Western Blot, ELISA.
• Other applications have not been tested.
• Recommended Dilution:Western Blot: 1:250-1:500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage, store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.