Alzheimer’s Disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain.
The major component of these plaques is Ab peptide (b-amyloid), a 40 to 43 amino acid peptide cleaved from amyloid precursor protein (APP).
Increased release of the ‘longer forms’ of Ab peptide, Ab42 or Ab43, which have a greater tendency to aggregate than Ab40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles, or may involve other, still undiscovered, factors.
Many researchers theorize that this increased release of Ab42/Ab43 leads to the abnormal deposition of Ab and the associated neurotoxicity in the brains of affected individuals.
Applications:Suitable for use in RIA, ELISA and Dot Blot.
Other applications not tested.
Recommended Dilutions:ELISA: 1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：25ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography
Form：Supplied as a liquid in PBS, pH 7.4. Carrier and preservative free.
Specificity：Recognizes human b-amyloid. Does not recognize beta amyloid 40 or beta amyloid 43.
Isotype：IgG
Calc Applications Abbrev：DB E RIA
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa36-42 within the C-terminal of human b-amyloid.
