84-1031-37　［取扱停止］Synuclein, alpha 50ug　S9500

特徴

• Synnuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals.
• In vertebrates they are encoded by three different genes.
• Synucleins have been specifically implemented in three major diseases: Alzheimer’s (AD), Parkinson’s (PD) and breast cancer.
• In AD, a peptide derived from alpha-synuclein forms an intrinsic component of plaque amyloid.
• In PD, an alpha-synuclein accumulates in Lewy bodies.
• An allele of alpha-synuclein has been linked to many familial cases of PD.
• In breast cancer increased expression of gamma synuclein correlates with the disease progression.
• Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry (frozen/paraffin): 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.