84-1031-36　Synphilin 1 50ul　S9116-07

特徴

• Synphilin 1 is a cytoplasmic protein that is enriched in the neurophils of normal human brain.
• Although the exact function of synphilin 1 is unknown, it may possibly have a role as a cytoskeletal protein based on the presence of ankyrin-like repeats and an ATP, GTP-binding domain.
• It has been shown to be novel is its ability to associate in vivo with alpha-synuclein to form cytoplasmic eosinophilic inclusions.
• Additionally, it has been observed to be present in Lewy bodies of Parkinson disease, which are composed of alpha-synuclein.
• Because synphilin 1 is not found in protein aggregates of Alzheimer’s disease, it appears to be specific for alpha-synuclein-containing lesions.
• Synphilin 1 may facilitate the aggregation of alpha-synuclein into Lewy bodies.
• Applications:Suitable for use in Immunohistochemistry and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:1000-1:2000.
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.