The function of the delta-opioid receptors has not been determined.
However, recent studies in rodents have linked delta-opioid receptor antagonists with prevention of morphine tolerance and dependence without relinquishing mu-opioid antinociception.
In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response.
The opioid signal is transduced from receptors through G proteins to various different effectors.
Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal.
For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channel activities.
Applications:Suitable for use in Immunohistochemistry.
