The ion channels activated by glutamate are divided into two classes.
Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR).
NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning.
NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death.
NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.
Western blot: 1:2,000 using ECL
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：25ug
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a lyophilized powder from ammonium bicarbonate (5mM) so some residual salt may also be present. Reconstitute with 50ul of PBS. Contains no preservatives.
Specificity：Specific for the NMDAR1 C2 splice variant. By Western blot recognizes a protein with MW of 100kD. Species Reactivity: Rat.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Rt
Immunogen：Peptide corresponding to the C-terminus of the rat NMDAR1 C2 splice variant.
