84-1029-63　Dopamine Receptor, D4 50ug　D9018-10

特徴

• Mouse Dopamine receptor D4 is a 387 aa, G-protein coupled and transmembrane receptor protein (1).
• This gene encodes the D4 subtype of the dopamine receptor.
• The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase.
• It is a target for drugs which treat schizophrenia and Parkinson disease.
• Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking.
• This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilutions:ELISA: 0.5-1ug/ml (1ug/ml immnogen peptide/well)Western Blot: 1-10ug/ml using chemiluminescence technique.
• ~100-400ug of membrane protein/lane should be loaded to visualize the receptor band.
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.