84-1029-46　Cytochrome P450 Enzyme CYP2E1 100ul　C9095-18D

特徴

• Cytochrome P450 (CYP) is a huge and diverse superfamily of hemoproteins.
• It metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone.
• Most CYPs can metabolize multiple substrates, and can catalyze multiple reactions.
• This accounts for their central importance in metabolizing the extremely large number of endogenous and exogenous molecules.
• In the liver, these substrates include drugs and toxic compounds as well as metabolic products such as bilirubin (a breakdown product of hemoglobin).
• Cytochrome P450 enzymes are present in many other tissues of the body including the mucosa of the gastrointestinal tract, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism.
• More than 7700 distinct CYP sequences are known as of September 2007.
• Applications:Suitable for use in Immunohistochemistry and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: Formaldehyde-treated and frozen sections.
• Optimal dilutions to be determined by the researcher.
• Recommended Positive Control:Liver tissue
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.