84-1028-83　Aquaporin 9 (AQP9) 100ug　A3000-40

特徴

• Water is a critical component of all living cells.
• Interestingly, tissue membranes show a great degree of water permeability.
• Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water.
• Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein “aquaporin”.
• Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues.
• A new member of AQP family, Aquaporin-9 (AQP9), has been cloned from human leukocytes by homology cloning.
• It is mostly homologous with AQP3 and AQP7 (54–48% identity).
• AQP9 (295 AA) is primarily expressed in peripheral leukocytes, and lesser amounts in liver, lung and spleen.
• AQP9 is permeable to water and urea.
• Unlike AQP3 and AQP7, it did not facilitate glycerol transport.
• AQP families of proteins are predicted to contain six transmembrane domains.
• The N and C-terminus are predicted to be cytoplasmic.
• Applications:Suitable for use in ELISA, Western Blot, though not tested, may potentially be used as an application.
• Other applications have not been tested.
• Recommended Dilutions:ELISA: 1:100,000.
• Using 50-100ng control peptide/wellOptimal dilutions to be determined by the researcher.
• Control Peptide:A3000-55: Aquaporin 9, Rat, Control Peptide (AQP9)
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.