84-1028-39　［取扱停止］F1Aa (FEM1b) 100ug　F0001-05

特徴

• Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family.
• A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aa and FEM1b (1,2).
• F1Aa/FEM1b is the homologue of C.
• elegans sex determining protein FEM-1 (1,2).
• FEM-1/F1Aa is cleaved by CED-3 and caspase (3).
• FEM-1/F1Aa associates with CED-4 and its mammalian homologue Apaf-1 (3).
• Overexpression of F1Aa induces apoptosis.
• F1Aa is therefore a novel member of the death receptor associated protein that mediates apoptosis.
• F1Aa is expressed in a variety of human and mouse tissues (1,2).
• Applications:Suitable for use in ELISA, Western Blotting.
• Other applications not tested.
• Recommended Dilution:Western Blotting: 0.5-1ug/ml.
• Optimal dilutions to be determined by the researcher.
• Positive Control: Mouse liver tissue
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%).
• Freeze at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.