84-1022-26　CARD9 (Caspase Recruitment Domain) 100ug　C1350

特徴

• Apoptosis is related to many diseases and development.
• Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules.
• CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC.
• A novel CARD containing protein was recently identified and designated CARD9, which interacts with the CARD activation domain of Bcl-10 (1).
• CARD9 associates with Bcl-10 and forms a complex within cells.
• CARD9 induces apoptosis and activates NF-kB.
• CARD9 is an upstream activator of Bcl-10 and NF-kB signaling.
• Applications:Suitable for use in ELISA, Western Blot and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 0.5-1ug/ml detects a band at 59kD
• Immunocytochemistry: 10ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Western Blot:P3113-99: PC-3 Cell Lysate Human Prostate AdenocarcinomaMDA-MB-361 cell lysateImmunocytochemistry:K0001-05: K562 Cell Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.