84-1022-21　Interleukin 21R, NT (IL-21R NT) 100ug　I8442-26

特徴

• A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 (1).
• The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2).
• IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3,4).
• Both IL-21R and the gc are necessary for the IL-21 function.
• IL-21 and its receptor activate JAK-STAT signaling pathway.
• IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines.
• IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
• Applications: Suitable for use in Western Blotting.
• Other applications not tested.
• Recommended Dilution: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Human Raji and A431 cell lysates can be used as positive control.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C or colder.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.