Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.
Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases.
A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 b Converting Enzyme) and caspase-13 (1).
Caspase-13 belongs to the ICE subfamily of caspases.
Overexpression of caspase-13 induces apoptosis.
Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis.
Caspase-13 is expressed in a variety of human tissues and cell lines (1).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
Positive Control: HL60 cell lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Highly Purified
Purity：Supplied as chromatographically purified IgG
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human, mouse and rat Caspase-13/ERICE. 43kD band should be detected.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Peptide corresponding to amino acids 91 to 105 of human Acaspase-13
