Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNF-R1 and Fas.
Several novel death receptors including DR3, DR4, and DR5 were recently identified.
A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6 (1).
Like TNF-R1, DR6 interacts with death domain-containing adapter molecule TRADD.
Overexpression of DR6 induces apoptosis and activates NF-kB and JNK.
DR6 is widely expressed in human tissues and cell lines (1).
The ligand for DR6 has not been identified.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Optimal dilutions to be determined by the researcher.
Positive Control: eLa and K562 whole cell lysate
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified IgG
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：An approximately 68kD band can be detected.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Peptide corresponding to amino acids 42 to 56 of human DR6 precursor (1).
