84-1014-80　ARC (CT) 100ug　A3325

特徴

• Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases.
• CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2.
• A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1).
• ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8.
• ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3.
• The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Positive Control: Whole cell lysate from HeLa cells
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.