84-1014-58　DcR2, ID (TRAIL-R4, TRUNDD, Decoy Receptor2, TNF receptor related receptor for TRAIL, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRUNDD, Tumor necrosis factor receptor superfamily member 10D precursor) 100ug　D1500-05

特徴

• Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors.
• TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines.
• DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor.
• Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD.
• DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis.
• Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues.
• Overexpression of DcR2 attenuated TRAIL-induced apoptosis.
• Applications:Suitable for use in Immunofluorescence, Immunocytochemistry, Immunohistochemistry, ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1ug/mlImmunohistochemistry (paraffin): 2.5ug/mlImmunocytochemistry: 10ug/mlImmunofluorescence: 20ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:HeLa cell lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.