Factor XIII is the zymogenic form of the glutaminyl-peptide-g-glutamyl transferase factor XIIIa (fibrinoligase, plasma transglutaminase, fibrin stabilizing factor), found in both extracellular plasma and intracellular platelets, megakaryocytes, monocytes, placenta, uterus, prostate and liver tissues.
Plasma Factor XIII is synthesized in the liver and circulates as a tetramer (Mr 320,000).
Factor XIII exists in plasma as a 340kD tetramer at a concentration of 10mg/L.
In this form it is known as Factor XIII (a2b2), this nomenclature reflects its structure, a tetramer of two pairs of identical chains held together by non-covalent bands.
The Factor VIII Zymogen is activated by thrombin, resulting in the formation of two dimers.
Factor VIII-A (a2 dimer) which has fibrin stabilizing activity by the catalysis of covelent bridges between fibrin monomers is the presence of calcium.
Factor VIII-S (b2 dimer) the biological role of which is unknown.
Applications:Suitable for use in ELISA and Immunodepletion.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Extinction Coefficient: ~14
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：1mg
Host：sheep
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in Hepes buffered saline, pH 6.5, 50% glycerol.
