84-1011-10　［取扱停止］Cyclic GMP (cGMP) 1000Tests　C8451

特徴

• Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP.
• Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC).
• Receptor activation of GC leads to the conversion of GTP to cGMP.
• Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme.
• Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
• Applications:Suitable for use in Immunohistochemistry and RIA.
• Other applications not tested.
• Recommeded Dilutions:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.