83-6576-34　Anti-Avelumab Polyclonal Antibody 50ug　AV974024

仕様

• サイズ：50ug
• Host species：Rabbit
• Specificity：The product is specific for Avelumab. This antibody serves as an excellent positive control for Avelumab immunogenicity (ADA) assays.
• Immunogen：Avelumab
• Form：Liquid
• Storage buffer：0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
• Clonality：Polyclonal
• Isotype：IgG
• Applications：ELISA
• Target：Rabbit polyclonal to Bavencio.
• Purification：Purified by antigen affinity column.
• Background：Avelumab with trade name Bavencio, is an FDA-approved drug to treat Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1) and therefore inhibits binding to its receptor programmed cell death 1 (PD-1). PD-L1 can be highly expressed on certain tumors, which is thought to lead to reduced activation of immune cells (cytotoxic T-cells in particular) that might otherwise recognize and attack the cancer. Inhibition of PD-L1 by Avelumab can remove this inhibitor effect and thereby engender an anti-tumor response. It is one of several ways to block inhibitory signals related to T-cell activation, a more general strategy known as "immune checkpoint inhibition.
• For research use only
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