Discription：Api m1, a glycoprotein of the phospholipase 2 （PLA2） family, is a major allergen of Apis mellifera （honeybee） venom （HBV） and a marker allergen for genuine sensitization to this venom. Api m 1 contributes 12-16％ of venom dry weight. Api m 1 is consistently found as a major allergen in HBV-allergic patients. Of the 12 known allergens within HBV, Api m 1 is considered the most prominent allergen, in terms of prevalence of sensitization, levels of specific IgE to Api m 1, and quantitative correlation between Api m 1 and HBV specific IgE. Api m 1 does not cross-react with phospholipases of the PLA1 family found in Vespid venoms, therefore, Api m 1 is a marker allergen allowing to discriminate between HBV and Vespid venom sensitization. Recombinant Api m1 is a 15.2kDa globular protein containing 134 amino acid residues.
