Discription：CCL20, also named LARC （Liver and Activation-regulated Chemokine） , is encoded by CCL20 located on chromosome 2 in humans. The expression can be induced by LPS and some inflammatory cytokines, and it is at a high level in lymph nodes, PBL, fatal liver, fatal lung, appendix and so on. CCL20 has functions of chemotactic towards lymphocytes and dendritic cells. Additionally, it promotes the adhesion of memory CD4+ T cells and inhibits colony formation of bone marrow myeloid immature progenitors. CCL20 elicits it effects by binding with CCR6 receptor. Recombinant Human MIP-3α is an 8.0kDa protein containing 70 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
