Discription：Interleukin-1 beta （IL-1β） is a non-secreted proinflammatory cytokine produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. The mature human IL1β shares 96％ amino acid sequence identity with rhesus and 67％-78％ with canine, mouse and rat IL-1β. Recombinant Human IL-1β is a 17.3kDa protein containing 153 amino acid.
