Discription：Epiregulin encoded by the EREG gene in humans, is a member of the EGF family of growth factors. This family also includes epidermal growth factor （EGF） , transforming growth factor （TGF） -alpha, amphiregulin （ARG） , HB （heparin-binding） -EGF, betacellulin, and the various Heregulin. Epiregulin is an EGF-related growth factor that binds specifically to EGFR （ErbB1） and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0kDa mature secreted sequence. Recombinant Human Epiregulin is a 5.6kDa monomeric protein, containing 49 amino residues, which corresponds to the mature secreted Epiregulin sequence.
