Discription：Interleukin-1 receptor antagonist （IL-1RA） is a member of the IL-1 family. IL1RA is secreted by various types of cells including immune cells, epithelial cells, and adipocytes, and is a natural inhibitor of the pro-inflammatory effect of IL1β. This protein inhibits the activities of interleukin 1, alpha （IL1A） and interleukin 1, beta （IL1B） , and modulates a variety of interleukin 1 related immune and inflammatory responses. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL1-RA. The regulated expression of IL1RA in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts the synthesis of IL-1RA is markedly enhanced by IL-1, TNF-alpha, or PDGF. The protein shows 26％ amino acid homology to IL1β and 19％ homology to IL1α. Recombinant Human IL-1RA is a 17.2kDa protein consisting of 153 amino acid residues.
