Discription：Novel Neurotrophin-1 （NNT-1） or B-Cell Stimulating Factor-3 （BSF-3） , is a new member of the IL-6 family of structurally related cytokines that includes IL-6, CNTF, LIF, CT-1, IL-11 and OSM. All family members share the receptor subunit gp130 that belong to the type I cytokine receptor superfamily. Ligand binding leads to gp130 homodimerization or heterodimerization （with LIF receptor or OSM receptor beta） , and induces cell signaling and functional activity. For several family members, including CNTF, IL-6, and IL-11, binding of the ligand to a specific receptor alpha subunit （CNTF R alpha, IL-6 R alpha, or IL-11 R alpha） is required prior to gp130 homo- or hetero-dimerization. Recombinant human NNT-1/BCSF-3 a 22.3kDa protein containing 198 amino-acid residues.
