Discription：IL-5, also named B-cell differentiation factor I, eosinophil differentiation factor and TRF, is belonging to the cytokine family and the IL-5 gene is in close proximity to the genes encoding IL-3, IL-4 and granulocyte-macrophage colony-stimulating factor （GM-CSF） , which are often co-expressed in TH2 cells. Through binding to the IL-5 receptor, IL-5 stimulates B cell growth and increases immunoglobulin secretion. It is also a key mediator in eosinophil activation. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma. The cDNA for murine IL-5 encodes a signal peptide and a 113 amino acid mature protein. Mature murine IL-5 shares 70％ and 94％ a.a. sequence identity with human and rat IL5 respectively. It shows cross-reactivity with human IL5 receptor. Recombinant Murine IL-5 is a 26.2kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.
