Discription：Interleukin-4 （IL-4） is a pleiotropic cytokine that induces differentiation of naive helper T cells （Th0 cells） to Th2 cells. It is produced by mast cells, activated T cells and bone marrow stromal cells. It has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. In addition, IL-4 enhances both secretion and cell surface expression of IgE and IgG1 and also regulates the expression of the low affinity Fc receptor for IgE （CD23） on both lymphocytes and monocytes. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The mouse IL-4 has a compact, globular fold, stabilized by three disulfide bonds. The human IL-4 shares about 40％ aa sequence identity with mouse/rat IL-4 and they are species-specific in their activities. Recombinant Murine IL-4 is a 13.5kDa globular protein consisting of 121 amino acid residues.
