Discription：Human CCL14 is belonging to the CC chemokine family. It has two isoforms, CCL14a （HCC-1） and CCL14b （HCC-3） . The sequence of HCC-3 differs from HCC-1 as follow： 27-27 R→ QTGGKPKVVKIQLKLVG. CCL14 was first isolated from the hemofiltrate of human patients with chronic renal failure. CCL14 promotes chemotaxis of T lymphocytes, monocytes and eosinophils, and inhibits infection of M-tropic human immunodeficiency virus type 1 and is a ligand for CCR1, CCR3 and CCR5. CCL14 is expressed constitutively in several normal tissues： spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations in plasma. Recombinant human HCC-1/CCL14 is an 8.4kDa protein containing 72 amino-acid residues including the four highly conserved cysteine residues present in the CC chemokines.
