Discription：IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. The human IL-22 gene is localized to chromosome 12q15. IL-22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R （previously an orphan receptor named CRF2-9） and IL-10R beta （previously known as CRF2-4） , belonging to the class II cytokine receptor family. Mature human IL-22 protein shares approximately 79％ aa sequence identity with mouse IL-22. Recombinant Human IL-22 is a 33.6kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.
