Discription：Human Interleukin-19 （IL-19） is encoded by the IL19 gene, which is located on the chromosome 1. The protein belongs to the IL-10 family that includes IL-10, IL-20, IL-22, IL-24, and IL-26. As a monomer made of seven amphipathic helices, IL-19 has a helical bundle and shares the same cell surface receptor （IL-20R） with IL-20 and IL-24. It may play some important roles in inflammatory responses because it up-regulates IL-6 and TNF-alpha and induces apoptosis through TNF-α. Human and murine IL-19 share 71％ amino acid sequence identity. Although mouse IL-19 is active on human cells, human IL-19 is not active on mouse cells. In solution, IL-19 exists predominantly as a non-disulfide-linked dimer. Recombinant Human IL-19 is a 17.9kDa globular protein containing 153 amino acid.
