83-6077-43　VMD2 (ARB, BEST, BMD, TU15B, VMD2) 50ul　470200

特徴

• This gene encodes a member of the bestrophin gene family.
• This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains.
• Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels.
• Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue.
• Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies.
• Alternative splicing results in multiple variants encoding distinct isoforms.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• AA Sequence:MFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYE NLPWPDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLG NVLILRSVSTAVYKRFPSAQHLVQAGFMTPAEHKQLEK LSLPHNMFWVPWVWFANLSMKAWLGGRIRDPILLQSL LNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFF LTCLVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVG WLKVAEQLINPFGEDDDDFETNWIVDRNLQVSLLAVD EMHQDLPRMEPDMYWNKPEPQPPYTAASAQFRRVS FMGSTFNISLNKEEMEFQPNQEDEEDAHAGIIGRFLGL QSHDHHPPRANSRTKLLWPKRESLLHEGLPKNHKAAK QNVRGQEDNKAWKLKAVDAFKSAPLYQRPGYYSAPQ TPLSPTPMFFPLEPSAPSKLHSVTGIDTKDKSLKTVSS GAKKSFELLSESDGALMEHPEVSQVRRKTVEFNLTDM PEIPENHLKEPLEQSPTNIHTTLKDHMDPYWALENRSV LHLNQGHCIALCPTPASLALSLPFLHNFLGFHHCQSTL DLRPALAWGIYLATFTGILGKCSGPFLTSPWYHPEDFL GPGEGR
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.