83-6050-09　MAP2K2 (Mitogen-Activated Protein Kinase Kinase 2, FLJ26075, MAPKK2, MEK2, MKK2, PRKMK2) 50ul　248432

特徴

• The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family.
• This kinase is known to play a critical role in mitogen growth factor signal transduction.
• It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3.
• The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.
• Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome.
• The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.
• A pseudogene, which is located on chromosome 7, has been identified for this gene.
• [provided by Re
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• AA Sequence:MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPTRTAV
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.