The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes.
This cytokine has pleiotropic effects in immunoregulation and inflammation.
It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages.
It also enhances B cell survival, proliferation, and antibody production.
This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway.
Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
[provided by RefSeq
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
AA Sequence:MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
抗体種類：Pab
宿主：mouse
Source Antibody：human
Grade：Purified
Purity：Purified
Form：Supplied as a liquid in PBS, pH 7.4.
Specificity：Recognizes human IL10.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：IL10 (AAI04253.1, 1aa-178aa) full-length human protein.
