83-6038-33　E2F6 (E2F Transcription Factor 6, E2F-6, MGC111545) 50ul　245565

特徴

• This gene encodes a member of the E2F transcription factor protein family.
• E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins.
• They are also a target of the transforming proteins of small DNA tumor viruses.
• Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain.
• The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains.
• It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription.
• The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max.
• Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.
• [provided by RefSeq
• Applications:Suitable for use in Immunofluorescence, Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• AA Sequence:MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINLEDNVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIDLVEKKSKNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERLAYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEELLEVSN
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.