Adapter molecule that regulates the activation of NF-kappa-B and JNK.
Plays a role in the regulation of cell survival and apoptosis.
The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14.
The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Applications:Suitable for use in Western Blot and Immunohistochemistry.