TRIM21 (Tripartite motif-containing protein 21; also Ro(SS-A), 52kD Ro Protein/Ro52, and RING finger protein 81) is a 52-56kD member of the RING finger-B-box-coiled-coil family of proteins.
It is an E3 ligase that is found in both nucleus and cytoplasm, where it is often associated with microtubules.
TRIM21 ubiquitinates select proteins.
In B cells, it targets the Fc fragment of misfolded IgG, providing QC on its production.
In macrophages, it acts in a nondegradative manner on IRF8, promoting innate immunity.
Human TRIM21 is 475aa in length and contains one E3 ligase RING finger domain (aa16-55), a B-Box type zinc-finger region (aa92-123), a coiled-coil region (aa128-238) and a C-terminal PRY/B30.2 Ig binding domain (aa268-465).
TRIM21 is reported to form trimers.
Over aa195-293, human TRIM21 exhibits 72aa identity with mouse TRIM21.
Applications:Suitable for use in Western Blot and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Immunofluorescence: 10ug/ml
仕様
Size：50ug
抗体種類：Pab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2.
Specificity：Recognizes human TRIM21.
Isotype：IgG
Calc Applications Abbrev：IF WB
Calc Crossreactivity：Hu
Immunogen：Full length human TRIM21, aa1-475 (NP_003132).
