Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan containing 198aa and belonging to the syndecan proteoglycan family.
Syndecan-4 functions as a receptor or coreceptor in intracellular signaling.
Initially, Syndecan-4 was isolated as ryudocan, from rat endothelial cells, and from human epithelial and fibroblastic cells, as amphiglycan.
The syndecan heparan sulfate chains of Syndecan-4 binds to HIV-1 gp120 and thus functions as trans HIV receptors.
This cell surface proteoglycan usually exists as a homodimer that interacts with CDCP1, with GIPC PDZ domain and with NUDT16L1/SDOS.
Reports suggest that Syndecan-4 is often upregulated in skin dermis after wounding, thus playing an important role in wound healing and angiogenesis.
It is also needed in satellite cell function and in the development and regeneration of skeletal muscle.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
AA Sequence:MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILFAVFLILLLMYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
抗体種類：Pab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2.
Specificity：Recognizes human SDC4.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Full length human SDC4, aa1-198 (NP_002990.2).
