83-6006-90　MAP2K4 (Dual Specificity Mitogen-activated Protein Kinase Kinase 4, MAP Kinase Kinase 4, MAPKK 4, MAPKK4, MKK4, JNK-activating Kinase 1, c-Jun N-terminal Kinase Kinase 1, JNKK1, JNKK, MAPK/ERK Kinase 4, MEK 4, MEK4, PRKMK4, SAPK/ERK Kinase 1, SEK1, SERK1, Stress-activated Protein Kinase Kinase 1, SAPK Kinase 1, SAPKK1, SAPKK-1, SKK1) 50ug　129372

特徴

• MAP2K4 is a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family.
• This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli.
• It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3.
• This kinase is phosphorylated, and thus activated by MAP3K1/MEKK.
• The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
• Applications:Suitable for use in Immunofluorescence and Western Blot.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 10ug/mlOptimal dilutions to be determined by the researcher.
• AA Sequence:MAAPSPSGGGGSGGGRGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.