83-6005-87　LGMN (PRSC1, Legumain, Asparaginyl Endopeptidase, Protease, Cysteine 1) 50ug　129073

特徴

• This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds.
• This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems.
• Enzyme activation is triggered by acidic pH and appears to be autocatalytic.
• Protein expression occurs after monocytes differentiate into dendritic cells.
• A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells.
• Overexpression of this gene may be associated with the majority of solid tumor types.
• This gene has a pseudogene on chromosome 13.
• Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
• These two variants encode the same isoform.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry (FFPE): 3ug/mlOptimal dilutions to be determined by the researcher.
• Amino Acid Sequence:MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGDAEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYRKMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVTHLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASEAEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHRIKLSMDHVCLGHY
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.